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KMID : 0359320140540040245
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Korean Journal of Veterinary Research
2014 Volume.54 No. 4 p.245 ~ p.252
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Evaluation of thermally cross-linked superparamagnetic iron oxide
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Hue Jin-Joo
Lee Hu-Jang
Jon Sang-yong
Nam Sang-Yoon
Yun Young-Won
Kim Jong-Soo
Lee Beom-Jun
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Abstract
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This study was investigated the change of concentration and toxicity of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) on tissues of Sprague-Dawley rats. TCL-SPION at the dose of 15 mg/kg body weight was intravenously injected into the tail vein of the male Sprague-Dawley rats. The fate of TCL-SPION in serum, urine and tissues was observed during 28 days. Serum iron level was maximal at 0.25 h postinjection and gradually declined thereafter. In addition, the sinusoids of liver and the red pulp area of spleen were mainly accumulated iron from 0.5 h to 28-day post-injection. In kidney, iron deposition was detected in the tubular area until 0.5 h after injection. Malondialdehyde concentration in the liver slightly increased with time and was not different with that at zero time. In the liver and spleen, TNF-α and IL-6 levels of TS treated with TCL-SPION were not different with those of the control during the experimental period. From the results, TCL-SPION could stay fairly long-time in certain tissues after intravenous injection without toxicity. The results indicated that TCL-SPION might be useful and safe as a contrast for the diagnosis of cancer or a carrier of therapeutic reagents to treat diseases.
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KEYWORD
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accumulation, biodistribution, rats, thermally cross-linked superparamagnetic iron oxide nanoparticles, toxicity
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